It can. It takes energy to cast, and more powerful spells use up more energy. It gets easier with practice, though. As long as you don't overdo it, you'll be fine after some rest.

[Which usually means sleep, but eating and generally taking it easy helps to.]

Worst case scenario, your magic won't recharge all the way and you'll be a little drained for a couple of days. That's happened to me a couple times. It's annoying, but nothing serious. Or permanent.